Not enough information to answer your question. However, as someone who works with VMware a great deal, I will give you this advice.
The easiest way to think about a VM is not as some "special" machine. But, rather think of it as a real physical box. Then, think to yourself: "If this was a real physical box, what would I do with it?"
Thus, if you had 2 machines in your network that you were considering patching, then I would patch them. If the network was isolated and for testing purposes, then I might not patch them.